CARDIOTOXICITY: AN UNUSUAL CASE OF METHOTREXATE OVERDOSE
نویسندگان
چکیده
The methotrexate (MTX) is an antimetabolite, whose dosages vary according to indication. It used in the treatment of tumoral pathologies, as acute lymphoblastic leukaemias and, rheumatology, rheumatoid polyarthritis (RP) and other chronic inflammatory rheumatisms belongs group antifolates: it inhibits purine pyrimidine synthesis, which accounts for its efficacy therapy cancer well some toxicities. Relative or absolute overdoses low-dose treatments non-oncological diseases are regularly reported, either isolated cases small series. bone marrow toxicity with thrombocytopenia leuconeutropenia most often first sign general involvement. cardiotoxicity very rare, this article we report observation pancytopenia associated a woman treated RA, whom etiological investigation revealed inadvertent intoxication by mistake dosage.
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ژورنال
عنوان ژورنال: International journal of advanced research
سال: 2021
ISSN: ['2707-7802', '2707-7810']
DOI: https://doi.org/10.21474/ijar01/12372